Advent® Dispersible Tablets

What is this product?

Advent® DT - dispersible tablets, combining two medicines: 400mg of Amoxycillin and 75mg of Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Amoxycillin against bacteria.
 

Why it's used

Advent DT Tablet is used to treat certain infections such as urinary tract infections which include inflammation of the kidney (pyelonephritis), and infection of the wall of the urinary bladder (cystitis), skin and skin structure infections such as serious bacterial skin infection (cellulitis), lower respiratory tract infections which include inflammation of the airways (bronchitis) or infection in the lungs (pneumonia). This medicine is also used to treat acute bacterial inflammation within the nasal passage (acute bacterial sinusitis), acute middle ear infection, gum swelling, and infection from animal bites. This medicine works by killing the growth of bacteria that cause infection.

When not to use

Advent DT will not work against colds, flu, or other viral infections.

Penicillin-class Antibacterial

Advent DT is a prescription medicine that belongs to a class of medicines called Penicillin-class Antibacterial. Penicillin are a group of antibiotics that are used to treat and prevent different type of bacterial infections.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Advent DT. Consume this medicine as per your doctor's instructions.

Advent DT is consumed with or without food. Advent DT should be taken with food to minimize the digestion difficulties of medicine. Advent DT may be taken every 8 hours or 12 hours, according to the prescribed dose and as directed. Do not take two doses in 1 hour.

The typical adult dose of Advent DT is 500 mg every 12 hours or 250 mg every 8 hours. The typical dose for children is 45 mg/kg (20.4 mg/lb)/day every 12 hours or 40 mg/kg (18.1 mg/lb)/day every 8 hours (patients aged 12 weeks and older) and 30 mg/kg (13.6 mg/lb)/day divided every 12 hours (neonates and infants aged less than 12 weeks). Advent DT is typically used at the same time every day. There are no known habit-forming tendencies with this medicine.

This medicine should be used on an as-needed basis. Advent DT should not be used more than 14 days without review. You should continue to use this medicine as directed by the doctor even if you feel well.
 

Tell your doctor if your condition persists or worsens or if you develop new symptoms. Talk to your doctor if skin rash, severe watery or bloody diarrhea, fever, difficulty in breathing, inflammation of the large intestine, stomach pain, fever, swollen glands in the neck, armpit or groin, swelling of the face or throat, inflammation of blood vessels, and collapse. If you have any kidney disease, the removal of amoxicillin may be delayed as the functioning of the kidney is not completely developed in neonates and young infants. Therefore, dose selection should be modified in these patients. Take necessary precautions while selecting a dose in elderly patients due to increased risk of side-effects.
 

If you are giving Advent DT Tablet to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
 

If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

If you are using the chewable tablet form of this medicine, make sure you chew the medicine before you swallow it.
 

To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
 

Limit drinking alcohol with Advent DT.
 

Medicines may be given for uses other than those listed in the medicine guide. Do not use Advent DT Tablet for symptoms for which it was not prescribed. Do not give Advent DT Tablet to others who may have similar symptoms as you. Self-medication can cause harm.

Store Advent DT Tablet at 25°C (77° F), away from moisture, and away from sunlight. Keep this medicine away from children and pets.

How to take Advent DT

How to take the medicine should be told by your health-care provider. Your dose and how often you take Advent DT will depend on the following factors:

• age
• weight
• patient's health
• the health of the patient's liver
• the health of the patient's kidneys
• medicines recommended by the doctor
• any other medicines being used
• herbal supplements in use
• response to the medicine

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time of the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Advent DT?

In the case of overdose, Advent DT should be discontinued, and symptomatic (treatment according to the symptoms) or supportive therapy should be given. Diuresis, hemodialysis (blood purifying techniques) and adequate fluid intake should be recommended to decrease the harmful effects of Advent DT.

Symptoms of an overdose of Advent DT

If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:

• cloudiness due to crystals in the urine (crystalluria)
• cramps
• decreased functioning of the kidney
• decreased output of urine
• diarrhea
• inflammation of the kidney (interstitial nephritis)
• nausea
• vomiting

If you think you have overdosed on Advent DT Tablet, call a poison control center immediately.

Precautions while using Advent DT

Before you use Advent DT Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
 

Before you use Advent DT, tell your doctor of your medical and health history including the following: penicillin allergy, allergy to multiple allergens, allergy to cephalosporins, abnormal functioning of the liver, difficulty in the flow of liver secretions (cholestatic jaundice), abnormal functioning of the kidney, inflammation of the colon due to bacteria (Clostridium difficile Associated Diarrhea), mononucleosis (an infectious condition caused by a virus), drug resistance, patients undergone urine testing to detect sugar levels, patients with history of asthma, hay fever and hives, or use of oral contraceptives. A life-threatening allergic reaction is observed in the patient with a history of allergy with penicillin and multiple allergens. An inflammation of the liver (hepatitis) and decrease flow of digestive fluid from liver (cholestatic jaundice) is observed in patients with a history of abnormal liver functioning. Use of this medicine may cause convulsions in patients with abnormal functioning of the kidney or taking a drug in high dose. Use of Advent DT in patients with Clostridium difficile associated diarrhea (CDAD) may kill the natural bacteria of intestine which lead to severe diarrhea. Redness and rashes of the skin may be observed in patients with a history of mononucleosis. Using this medicine in improperly diagnosed bacterial infection may lead to the development of resistance in bacteria against the drug.
 

The use of this medicine may change blood clotting parameter (prothrombin time). Use of Advent DT may increase the prothrombin time. Patients should be monitored carefully.

The use of Advent DT Tablet may change blood estrogen level. Advent DT may decrease the levels of blood estrogen hormone (estriol, estriol-glucuronide, conjugated estrone, and estradiol) during pregnancy.
 

The use of this medicine may change liver enzymes (aspartate aminotransferase and alanine aminotransferase). Abnormal functioning of the liver and elevated levels of liver enzymes are observed in patients taking Advent DT for a long time.
 

Advent DT Tablet can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Advent DT Tablet can worsen the sleepiness. Advent DT Tablet may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.
 

The use of Advent DT Tablet during pregnancy should only be when required. Advent DT should be avoided during pregnancy unless it is necessary during pregnancy. The use of Advent DT Tablet Advent DT Tablet while breastfeeding should only be when required. Advent DT may pass into breast milk and can cause diarrhea and fungal infection in the breastfed infant, so Advent DT should only be used with precaution or after assessment of risks and benefits of the drug during breastfeeding by the doctor. Consult with your doctor on the use of Advent DT Tablet, if you are trying to conceive.
 

Limit drinking alcohol with Advent DT.
 

Advent DT may cause increased incidence of side-effects in older patients. Elderly patients may see an increased risk of inflammation of the liver (hepatitis), difficulty in the flow of bile from liver (cholestatic jaundice), and increased liver enzymes.
 

Advent DT may cause an increased risk of side-effects in children. Children using this medicine may see an increased risk of diarrhea, skin rashes, hives, diaper area rashes, and tooth discoloration.
 

If this medicine is used for long-term may cause complications like inflammation of the liver (hepatitis), the decrease in bile flow from liver (cholestatic jaundice) and increased levels of liver enzymes.

Advent DT Side-effects

The following side-effects may commonly occur when using Advent DT Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:

• diarrhea
• hives
• immune disorder of T cells (mucocutaneous candidosis)
• inflammation of the vagina
• nausea
• skin rashes
• vomiting

The following side-effects may commonly occur in older patients on the use of Advent DT Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:

• decrease in flow of bile from liver (cholestatic jaundice)
• increased liver enzymes (aspartate aminotransferase, alanine aminotransferase)
• inflammation of the liver (hepatitis)

The following side-effects may commonly occur in children when using Advent DT Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:

• diaper area rashes
• diarrhea
• hives
• skin rashes
• tooth discoloration

Rarely, the use of Advent DT Tablet may cause the following side-effects:

• behavioral changes
• black hairy tongue
• cloudiness due to crystals in the urine (crystalluria)
• dizziness
• gas formation (flatulence)
• headache
• increase in the number of eosinophils (eosinophilia)
• indigestion
• inflammation of the kidney (interstitial nephritis)
• inflammation of the tongue (glossitis)
• insomnia
• overgrowth of non-susceptible organisms
• reversible hyperactivity
• severe itching of the skin
• stomach discomfort
• tooth discoloration

The following severe side-effects may also occur when using Advent DT Tablet:

• blood disorder
  Symptoms: deficiency of red blood cells (hemolytic anemia), low levels of thrombocytes, low levels of the blood cells, low levels of leukocytes low level of granulocytes
  If any of these reactions occur, discontinue the use of Advent DT.
  
• stomach and intestinal disorders (possible fatal)
  Symptoms: inflammation of the colon due to bacteria (antibiotic-associated colitis), inflammation of both the small intestine and the colon (enterocolitis), inflammation of the stomach lining (gastritis) painful swelling and sores inside the mouth
  Discontinue the use of Advent DT, if inflammation of the colon due to bacteria (antibiotic-associated colitis) occur. Appropriate electrolyte and fluid management, antibacterial treatment of inflammation of the colon, protein supplementation, and surgical evaluation should be recommended.
  
• kidney disorder
  Symptoms: blood in the urine (hematuria)
  Inform your doctor immediately if you experience any of these side effects.
  
• skin and immune system disorders such as allergic reaction (possibly fatal)
  Symptoms: life-threatening skin reaction (Stevens-Johnson Syndrome), life-threatening drug-induced skin reaction (harmful epidermal necrolysis/drug reaction with eosinophilia and systemic symptoms (DRESS)), red skin rash with small pus-containing blisters (bullous exfoliative dermatitis), blisters and red, scaly rash with bumps under the skin (exanthemous pustulosis), flu-like symptoms, skin allergic reaction caused by infection (erythema multiforme), allergic reaction to an injection of foreign protein, swelling of the face or throat, inflammation of blood vessels (allergic vasculitis) life-threatening allergic reaction (anaphylactic reactions/anaphylaxis)
  If an allergic reaction occurs, discontinue the use of Advent DT, and appropriate therapy should be recommended.
  
• central nervous system disorder
  Symptoms: convulsions, inflammation of the brain and spinal cord membranes (aseptic meningitis), agitation, anxiety confusion
  Inform your doctor immediately if you experience any of these side effects.
  
• liver disorders (possible fatal)
  Symptoms: inflammation of the liver (hepatitis), difficulty in the flow of liver secretions (cholestatic jaundice), increased aspartate aminotransferase increased alanine aminotransferase
  Inform your doctor immediately if you experience any of these side effects.
  

Your doctor has prescribed Advent DT Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Advent DT Tablet.

Interactions with Advent DT

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.

Your doctor's guidelines may need to be followed while taking this medicine along with false-positive reactions. Patients using Advent DT or amoxicillin alone during testing of glucose in urine using Benedict's solution, Fehling's solution or testing kit may see an increased risk of false positive reactions. Enzymatic glucose oxidase reactions based glucose test should be recommended in such patients.
 

Advent DT Tablet interacts with allopurinol, which is used to treat redness and tenderness in the joints (gout). Patients using amoxicillin with allopurinol may experience the increased occurrence of rashes as compared to patients taking amoxicillin alone. It is unknown whether the increased incidence of rashes is due to the combined usage of amoxicillin with allopurinol or due to increased levels of uric acid (hyperuricemia) in patients.
 

There may be an interaction of Advent DT with oral anticoagulants (acenocoumarol and warfarin), which are used to prevent blood clotting. The use of amoxicillin in combination with oral anticoagulants may abnormally increase the bleeding time in patients. Careful monitoring of blood clotting parameter, with the use or withdrawal of amoxicillin and dose adjustment of oral anticoagulants, is recommended in patients using anticoagulants with Advent DT.
 

Advent DT Tablet may interact with probenecid, which is used to treat redness and tenderness in the joints (gout). Probenecid decreases the secretion of amoxicillin in the kidney. The use of Advent DT with probenecid may increase the level of amoxicillin in the blood. Patients should not use probenecid with Advent DT.
 

Special instructions need to be followed while taking this medicine along with oral contraceptives, which are used to prevent unwanted pregnancy. The use of Advent DT may affect the natural bacteria of the digestive tract which may lead to decreased hormone reabsorption and reduced the effectiveness of oral contraceptives.

There may be an interaction of Advent DT with mycophenolate mofetil, which is used to prevent rejection in organ transplantation. The use of Advent DT with mycophenolate mofetil may decrease the level of mycophenolate mofetil in the blood. Doctors should monitor the patients carefully as soon as possible after antibiotic treatment and during the combination therapy.
 

Advent DT Tablet may interact with methotrexate, which is used to treat cancer. Use of penicillins may decrease the excretion of methotrexate which may lead to increased harmful effects.
 

This page does not contain all the possible interactions of Advent DT Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.